Endocrine Abstracts

Background: High oxidative stress is associated with increased morbidity. The effect of testosterone treatment (TT) on oxidative stress in ageing men with reduced bioavailable testosterone is undetermined.Aim: To determine the effect of TT compared to placebo on oxidative stress biomarkers.Methods: Double-blinded, placebo-controlled study in 38 men, aged 60–78 years, with bioavailable testosterone <7.3 nmol/l and waist cir...

Background: Increased oxidative stress has been linked to both hypo- and hyperthyroidism. Whole-body oxidative stress can be estimated by the oxidized guanine nucleosides, 8-oxo-7.8-dihydroguanosine (8-oxoGuo) and 8-oxo-7.8-dihydro-2’-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These biomarkers have been associated with increased morbidity and mortality in several diseases but are not well explored in humans with thyroid disorders.<p class="abst...